Endometriosis and Supplements: Evidence-Based Relief for Pain
Do you have a shelf at home brimming with supplements that were recommended to help alleviate your endometriosis pain? Perhaps you've been exploring ways to improve egg quality, increase your chances of conception, or reduce symptoms like nausea, GI discomfort, or fatigue?
In this blog, we’ll dive into the research behind supplements for endometriosis to help you make informed choices for managing your symptoms effectively. From pain relief to reducing inflammation, discover which supplements may support your journey toward relief.
Supplements for Endometriosis Pain Relief
Pain is a hallmark symptom of endometriosis. If you’re seeking natural ways to reduce pain, research points to the potential benefits of specific supplements.
Vitamin C and Vitamin E Combination
A study involving women aged 15–45 found that a combination of 1000 mg of vitamin C and 800 IU of vitamin E significantly reduced pain associated with menstruation, intercourse, and chronic pelvic pain compared to a placebo. Another study noted a 43% reduction in chronic pain and a decrease in pain with intercourse by 37% for participants taking this supplement duo.
Takeaway: Combining vitamin C and E may be effective for addressing various types of endometriosis pain.
Vitamin D
Vitamin D supplementation (50,000 IU weekly or bi-weekly) showed some improvement in pelvic pain, though the results were not statistically significant. Still, ensuring adequate vitamin D levels is crucial for overall health and immune function.
Magnesium
Magnesium has shown promise in reducing prostaglandin levels, which play a role in inflammation and pain. In a study, 21 out of 25 participants reported pain reduction after six months of magnesium supplementation.
Zinc
While not specific to endometriosis, research suggests that 30 mg of zinc taken 1–3 times daily before menstruation may reduce menstrual pain and PMS symptoms. Other studies show zinc deficiency is a risk factor for endometrioma development.
Probiotics: Lactobacillus gasseri
The probiotic strain Lactobacillus gasseri has been studied for its anti-inflammatory effects and its potential to alleviate menstrual pain associated with endometriosis.
Omega-3 Fatty Acids: Reducing Inflammation
Omega-3 fatty acids are known for their anti-inflammatory properties. Studies indicate that omega-3 supplementation can lower pain scores by up to 50% in endometriosis patients. Adequate intake may also reduce the production of inflammatory cytokines, proteins linked to endometriosis-related inflammation.
N-Acetylcysteine (NAC)
NAC, an antioxidant, has demonstrated benefits for reducing pelvic pain and even the size of endometriomas. A study using 600 mg of NAC three times daily showed significant reductions in pain, and 75% of participants achieved spontaneous pregnancy within six months.
For enhanced effects, NAC has been studied in combination with alpha-lipoic acid (ALA) and bromelain, showing reduced pain and a decreased need for pain-relieving medications.
Pycnogenol
Pycnogenol, derived from pine bark extract, has shown promising results in reducing symptoms and CA-125 levels (a marker of deep infiltrating endo and inflammation, conventionally used to assess for gynecological cancers) in patients. Studies suggest that 60 mg daily may alleviate pain and improve overall well-being.
Ginger and Menstrual Pain Relief
Ginger has a long history as a natural remedy for menstrual pain. Research suggests doses between 50 mg twice daily to 500 mg three times daily can reduce pain effectively.
Melatonin: For Pain and Sleep
Melatonin, known for its role in regulating sleep, also provides pain-relieving benefits. A study demonstrated a 40% reduction in daily pain and a significant improvement in sleep quality with 10 mg of melatonin supplementation.
Summary of Recommended Supplements
If you’re considering supplements to manage endometriosis, here’s a quick overview of the most promising options:
Vitamin C + Vitamin E: 1000 mg + 800 IU
Vitamin D: 50,000 IU every two weeks
Lactobacillus gasseri: Probiotic strain
Zinc: 30 mg before menstruation
Magnesium: Daily as per guidelines
Omega-3s: 1.5–3 g daily
NAC: 1800 mg daily or in a combo (600 mg NAC, 200 mg ALA, 35 mg bromelain)
Pycnogenol: 60 mg daily
Melatonin: 10 mg daily
Final Thoughts
While supplements can provide support, they should complement a comprehensive treatment plan. Always consult with your healthcare provider before starting new supplements, especially if you’re on medication or managing other health conditions.
For those navigating the challenges of endometriosis, finding relief is a journey. By integrating evidence-based supplements into your routine, you may be able to reduce pain and improve your quality of life. Kean on letting someone else take the reins as you navigate endometriosis? Apply to work with me inside the Endo Thrive Society. Hope to see you inside!